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Hello tig and welcome to the forums
If you use the search facility and input 'central locking' you will find a whole host of threads on the very same subject/problem you are enquirying about.
Mostly, the cause is to do with water ingress into the infra red unit housed infront of the sunroof by the internal light.
Have a read through what you find in the search and you will probably find your answer.
Currently in scatz's garage:
2004 Subaru Legacy GT Spec B, a 2013 2.0 TDCi Titanium X Sport S-Max and a 2001 Honda NSR125R